Clinical features of myasthenia gravis with neurological and systemic autoimmune diseases

Multiple reports on the co-existence of autoimmune diseases and myasthenia gravis (MG) have raised considerable concern. Therefore, we reviewed in MG to explore their clinical presentations determine whether presence affects disease severity treatment strategies for MG. We all major immune-mediated coexisting conditions associated with PubMed, Embase Web Science were searched relevant studies from inception January 2023. There is a higher frequency concomitant patients than general population marked risk women. Most comorbidities are linked AChR-MG; however, there few MuSK-MG. Thyroid disorders, systemic lupus erythematosus, vitiligo most common system In addition, can coexist neurological diseases, such as neuromyelitis optica (NMO), inflammatory myopathy (IM), multiple sclerosis (MS), encephalitis (AE), NMO being common. Autoimmune appear develop more often early-onset (EOMG). MS coexists commonly EOMG, while IM LOMG. complicated by tends mild manifestations, coexistence does not influence course The typically severe. occur after or combined abnormality; therefore, timely thymectomy followed immunotherapy could be effective. thymoma-associated AChR an increased AE IM, whereas thymic hyperplasia. co-occurrence attributed similar immunological mechanisms different targets genetic factor predisposition. This review provides evidence association between several comorbid diseases.